Sodium ya Tianeptine CAS: 30123-17-2 5-dioxyde Stablon S-Dioxide Umunyu wa Sodium

UKORESHE

Umunyu wa sodium ya Tianeptine ni antidepressant ya tricyclic, kandi uburyo bwayo bwo kurwanya antidepressant butandukanye na antidepressant gakondo ya tricyclic.Irashobora kongera reuptake ya 5-HT mumwanya wa synaptic, kandi irashobora kugira ingaruka zo kunoza imiyoboro ya 5-HT neuron.Ntaho bihurira na choline cyangwa reseptor ya adrenaline.Imiti igabanya ubukana isa na tricyclic, ariko kwihanganira ni byiza kuruta tricyclic.Mu bushakashatsi bw’inyamaswa, irashobora kongera ibikorwa byizana bya selile piramide muri hippocampus kandi byihutisha gukira kwayo nyuma yo kubuza imikorere.Igitabo cyimiti cyongereye reabsorption ya serotonine na neuron muri cortre cerebral cortex na hippocampus.Kwinjiza sodium ya tineptine mu nzira y'ibiryo byihuta kandi byuzuye.Gukwirakwiza vuba, PPB kugeza kuri 94%.Yahinduwe mu mwijima na β-okiside na N-demethylation, kandi gukuraho T1 / 2 byari bigufi kuri 2.5h.Umubare muto cyane wibiyobyabwenge (8%) wasohotse mu mpyiko, cyane cyane metabolite ziva mu nkari.Abarwayi bafite ikibazo cyo kubura impyiko bahanaguye T1 / 2 kuri 1h yaguye.