Teduglutide CAS: 197922-42-2 Isubiramo ALX 0600 Gattex

Igikorwa:
Teduglutide, izwi mu Cyongereza nka Teduglutide, ni analogue ya glucagon imeze nka peptide 2 (GLP-2), imisemburo isanzwe ibaho igabanya gusohora igifu no gusohora kandi ikagenga imikurire, ikwirakwizwa, no gusana ingirabuzimafatizo zo mu nda.Umuti wongera umubare w'utugingo ngengabuzima, wongera kwinjiza mu mara mato kandi ukagabanya impiswi.
Imyiteguro:
Imiterere yimpeta zigizwe nabantu batanu zifitanye isano cyane na aside amine iburyo ya Asp cyangwa Asn, kandi Gly nuburyo bworoshye bwimpeta iyo Gly ihujwe mbere ya Asp kubera kubura itsinda ririnda hamwe nimbogamizi nke za steric kuruhande urunigi.Kubwibyo, byanze bikunze uburyo bwo guhuza urutonde bizatuma N-terminal amino acide ya Teduchemicalbook lupeptide ikora impeta yabanyamuryango batanu mugikorwa cya synthesis, bityo bikagabanya ubuziranenge.Kubwibyo, kugirango dukemure ikibazo cyo gutesha agaciro igice cya Asp-Gly, igice kirinzwe rwose hamwe nimiterere yerekanwe muri SEQIDNO: 2 cyabanje guhuzwa no guhuza ibice.Igice cyarinzwe rwose ni aside ya mbere ~ ya kane ya amino acide ya N-terminal ya tidulutide, harimo imiterere ya Asp-Gly, hanyuma igice kirinzwe cyuzuye cyezwa.Igice cyasukuwe neza cyarinzwe cyari icyiciro gikomeye gifatanije nigice cya peptide resin hamwe nuburyo bwerekanwe muri SEQIDNO: 12, hanyuma clavage ya nyuma ikorwa kugirango tidurotide