Gutanga ibicuruzwa Dihexa CAS 1401708-83-5

Ikoreshwa:

DIHEXA (PNB-0408), reagent ya oligoplase, ni igereranya rya IV ryerekana imiyoboro y'amaraso ya IV hamwe n'ibikorwa byo mu kanwa hamwe n'ubwonko bwamaraso.Dihexa-nshuti nyinshi nimbaraga zihuza ibintu bikura hepatocyte (HGF), ChemicalBookkd agaciro ni 65PM, kandi ikazamura ibikorwa byayo kuri reseptor C-MET.Dihexa yerekana ibikorwa byiza birwanya -ejaculation no kunoza imikorere yubwenge mubyitegererezo byinyamaswa.Dihexa ifite ubushobozi bwo kwiga indwara ya Alzheimer.

Dihexa ihuza cyane na HGF hamwe na dihexa yombi hamwe nuruvange rwababyeyi Norleucine 1-AngIV itera c-Met fosifora imbere yibitekerezo bya HGF hamwe no kongera selile ikwirakwizwa na HGF.Byongeye, dihexa na Nle1-AngIV bitera hippocampal spinogenezi na synaptogenezi isa na HGF ubwayo.Dihexa irabuza neza dimerisation ya HGF kuri 1 mμM. Mugihe dihexa kuri 1 nM na 10 pM yonyine idakora c-Met, yongereye cyane ubushobozi bwa HGF kuri 1.25 na 2.5 ng / mL kugirango ikore c-Met.

Dihexa ifite igihe kirekire kizenguruka igice cyubuzima.Dihexa yerekana ibikorwa byo kumenyekanisha.Dihexa ihindura scopolamine iterwa na deficits yo kwigira.Itezimbere imyigire yimbeba zishaje.Dihexa itera spinogenezi muri neuron yimico ya hippocampal.