Inhibitor GW0742 CAS 317318-84-6 Ifu ​​yera

Andarine (S-4) ni uruganda rukomoka kuri arylpropionamide [S-3- (4-acetylamino-phenoxy) -2-hydroxy-2-methyl-N- (4-nitro-3-trifluoromethyl-phenyl) -propionamide] ubanza byasobanuwe na Yin n'abandi.kuba moderi ya androgene yakira modulator (SARM).Andarine (S-4) yerekanwe na vitro no mubushakashatsi bwa vivo ko ari agoniste mwiza wa anabolike, nta ngaruka mbi zikunze kuba zifitanye isano na anabolike-androgeneque steroyide, bifitanye isano ahanini no gukuramo isano ya 5α-reductase kugirango itange DHT muri prostate.
Igikorwa cya farumasi ya andarine cyerekana imbaraga nyinshi za andarine mugutezimbere kwa SARMs ziboneka mumavuriro, zitanga inyungu zidasanzwe zo kuvura kurenza bagenzi babo ba steroidal hamwe numwanya ushimishije wo gutandukanya itandukaniro rya androgene mumyanya itandukanye, bityo bikagabanya kwivanga mubisanzwe .Rero, andarine ifite ibyiringiro mubigeragezo byamavuriro bigamije kuvura indwara ziterwa nimyaka no kurwanya ibimenyetso byindwara zikomeye nka sarcopenia na kanseri cachexia.
Andarine ni selitori idasanzwe ya androgene reseptor (AR) agonist hamwe na Ki ya 4 nM.Andarine yerekana ibikorwa bikomeye kandi byiza bya anabolike kandi bikavamo gutera imbaraga ziterwa no gukura kwa prostate, semic seminal.Andarine ifite ubushobozi bwo kurwanya antosteoporotic.
Andarine (yahoze yitwa GTx-007; S-4; GTx007; S4) ni bioaktique yo mu kanwa kandi itoranya reseptor ya androgene reseptor (AR) agonist, cyane cyane ihitamo reseptor ya moderi (SARM), ifite akamaro ko guta imitsi. na osteoporose.Ikora AR hamwe na Ki ya 4 nM kandi ni tissue-ihitamo ingingo za anabolike.Andarine iri gukorwa iperereza kugirango ivure indwara nko guta imitsi, osteoporose na hypertrophy nziza ya prostate.Mubyitegererezo byinyamanswa ya hypertrophyi ya prostate nziza, andarine yerekanwe kugabanya ibiro bya prostate hamwe ningaruka zisa na finasteride, ariko nta kubyara kugabanuka kwimitsi cyangwa ingaruka mbi zo kurwanya andorogene.