Ubushinwa Bugurisha CAS 7361-61-7 Ifu yera ya Xylazine

Ibisobanuro

Xylazine ni agoniste wa α2-adrenergic reseptors (Ki = 194 nM).Ni ikigereranyo cya clonidine, α2-adrenergic reseptor agonist ikoreshwa mu kugabanya umuvuduko wamaraso.Xylazine ikoreshwa mu kwikinisha, anesteziya, no analgesia mu nyamaswa z’inyamabere.Iki gicuruzwa nacyo kiraboneka nkigipimo cyisesengura.
InkomokoXylazine, Bayer

Gukoresha

Antinociceptive; Alpha-2 adrenergic agonist
Gukoresha

Xylazine ni α2 icyiciro cya adrenergic reseptor agonist.Xylazine ni analoque ya clonidine ikora kuri reseptor ya presynaptic na postynaptic nka 2-adrenergic agonist.
Uburyo bwo gukora

2,6-Dimethylphenyl isothiocyanate, 31.0 g (0,2 mole), yateguwe kuva 2,6- dimethylaniline hamwe na thiophosgene, yongewemo ibitonyanga mu minota 15 kugirango ihagarike neza ya 15.0 g (0,2 mole) ya 3-aminopropanol-1 muri Ml 100 ya ether.Ether yatangiye kubira.Gukangura munsi ya repux byakomeje kuminota 30, hanyuma ether irayitandukanya.Ibisigara byavuwe hamwe na ml 100 ya acide hydrochloric yibanze hanyuma bitekwa munsi ya minisiteri 30 min.Nyuma yo gukonjesha, yashizwemo n'amazi, ayungurura nta mwanda, kandi umusingi waguye hongewemo umuti wa sodium hydroxide yibanze.Iyo wongeye gushyirwaho uhereye kuri benzene-ligroin, ibivanze bivamo 2- (2,6- dimethyl-phenylamino) -4H-5,6-dihydro-1,3-thiazine, gushonga ingingo 140-142 ° C (gutanga 90% bya theoretical ).
Imikorere yo kuvura

Analgesic, Anesthetic

Ibisobanuro rusange

Xylazine irashonga muri methanol (50 mg / ml), itanga igisubizo gisobanutse, kitagira ibara.Irashobora kandi gushonga muri acide ya HCl no muri chloroform.Xylazine ntishobora gushonga mumazi no mubisubizo bya alkali.
Ibikorwa bya Biochem / physiol

Xylazine iyo ikoreshejwe hamwe na ketamine ifatwa nkineste ikomeye kandi itekanye mumatungo yubushakashatsi.Birazwiho kuzamura umwijima wa glucose, wongera hyperglycemia.
Uburyo bwibikorwa

Xylazine igurishwa nkumunyu wa hydrochloride nka Rompun (100 mg / mL) na Anased (20 mg / mL) ibisubizo byatewe kugirango binjire mu mafarasi n'imbwa.Ibikorwa bya xylazine birashobora guhindurwa nubuyobozi bwa yohimbine, alkaloide indolalkylamine, ibuza izo α2- adrenoreceptors ziterwa na xylazine.
Umwirondoro wumutekano

Uburozi mukunywa, inzira zidasanzwe, ninzira zinjira.Ingaruka za sisitemu zabantu: impinduka mubikorwa bya moteri, kugwa kumuvuduko wamaraso, miose, kubyimba kwinshi, umuvuduko wimpanuka ugabanuka, somnolence.Iyo ishyutswe kugirango ibore isohora imyotsi yubumara ya NOx na SOx